McMurry Chemistry Students, Faculty Attend Regional Meeting

  Gary Ellison
  Monday, December 4, 2017 8:48 AM
  Archives 2016 - 2017

Abilene, TX

A team of faculty and students from the chemistry department at McMurry University recently attended the American Chemical Society Southwest Regional Meeting (ACS-SWRM) in Lubbock, Texas on October 28 – November 01, 2017. 

Faculty attending were Drs. Pyenta and Donnay. Students attending were Alisa Rasley '19, Haley Shepard '19, Megan Butler '17, Bethany Everett '19, Kelsey McKiernan '17, and Liyha Stotts '21.

Regional meetings are an excellent opportunity for both students and faculty to establish networking connections, plug-in to the regional chemical / biochemical community, and gain exposure to current scientific projects at both large and small universities.  McMurry presented three posters detailing the recent research efforts of our students as guided by faculty members. 

Abstracts giving more detailed descriptions, and photos, are:

Cytotoxic response of MDA-MB-231 and MCF-7 breast cancer cells to
mono- and bi-hydroxamic acid derivatives as histone deacetylase

Alisa Rasley,, Haley Shepard, Paul S. Pyenta.  Chemistry, McMurry University, Dyess AFB, Texas, United States

Histone deacetylase (HDACs) are overexpressed in several cancer types, and inhibition of HDACs can result in anti-cancer effects through various
mechanisms involving reduced cell motility/migration, invasion, angiogenesis, proliferation, induction of apoptosis, and inhibition of DNA repair. As a consequence, HDAC inhibitors (HDACi’s), such as suberoylanilide hydroxamic acid (SAHA, or “Vorinostat”) and related compounds, are identified as novel anti-cancer drugs. Several previously synthesized compounds in our lab were tested on the breast cancer cell lines Michigan Cancer Foundation-7 (MCF-7) and MD Anderson Breast Adenocarcinoma
(MDA-MB-231) using cell assays water-soluble tetrazolium salts (WST-1)
(Roche), which reports cell proliferation, and cytotox-96 (Promega), which reports cell death; assays are colorimetric and numeric results are measured sing a 96-well plate reader. Cells were exposed to inhibitors at 0.1 - 100 µM ranges for 24 or 48 hours. Results from our study indicate potential anticancer activity for some compounds compared to SAHA. Future studies will examine greater concentration doses and longer exposure time periods.


Comparison of microwave-assisted and conventional synthesis of
histone deacetylase inhibitors as potential anti-cancer agents

Bethany Everett2,, Hyunshun Shin3, Paul
Pyenta1, Mukundwa Gael1, George Gutierrez1. (1) Chemistry & Biochemistry,
McMurry University, Abilene, Texas, United States (2) Chemistry and
Biochemistry, McMurry University, Abilene, Texas, United States

Histone deacetylases (HDACs) are overexpressed in several cancer types, and inhibition of HDACs can result in anticancer effects through various
mechanisms such as reduced cell motility/migration, invasion, angiogenesis, proliferation, induction of apoptosis, and inhibition of DNA repair. We designed HDAC inhibitors based on structure-activity studies (SARs) from the interactions between Suberoylanilide hydroxamic acid (SAHA) and both HDAC1 and HDAC8. N-hydroxy-6-phenoxyhexanamide derivatives with fluorine in the –ortho, -meta, -para positions were made by traditional reflux
methods and microwave assisted synthesis. The traditional reflux method shows a higher percent yield of product as compared to microwave assisted synthesis. The synthesized products will be tested for anticancer activity on MDA-MB-231 and MCF-7 breast cancer cell lines in the future.


Synthesis of DPPZ ligand analogs and their Cr(III) polypyridyl complexes

Megan Butler,, Edward G. Donnay. Chemistry and
Biochemistry, McMurry University, Abilene, Texas, United States

The photosensitizer is the key component in photodynamic therapy which is used to treat a variety of medical conditions including cancer. An important factor in the development of polypyridyl metal complexes as photosensitizers is to increase their binding affinity for DNA. One way to achieve this goal is to incorporate a ligand that can intercalate or slip between the base pairs of DNA. The dipyrido[3,2-a:2′,3′-c]phenazine or DPPZ ligand is well known to intercalate and therefore the photophysical and DNA binding properties of Ru(II) and Cr(III) polypyridyl complexes containing DPPZ have been studied. Several Ru(II) polypyridyl complexes containing analogs of the DPPZ ligand
that are substituted or have extended conjugated pi systems have also been made and characterized, but few Cr(III) complexes containing DPPZ analogs have been reported. This study investigates the synthesis of two ligands, 11-carboxydipyrido[3,2-a:2′,3′-c]phenazine (DPPA) and phenanthro[4,5-abc]dipyrido[3,2-h:2′,3′-j]phenazine (PADPPZ) and attempts to prepare the corresponding chromium complexes, [Cr(phen)2(DPPA)]3+ and [Cr(phen)2(PADPPZ)]3+, where phen is 1,10-phenanthroline. Organic products
were characterized by their melting points, IR, and NMR spectra while chromium complexes are generally characterized through ultraviolet-visible spectroscopy, steady-state emission measurements, cyclic voltammetry, elemental analysis, and mass spectrometry.



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